Stop, Reduce and Relieve with Daflon

An oral treatment for leg pain, varicose veins, edema and other symptoms of chronic venous insufficiency. 1

Answer 5 short questions to assess your symptoms and risk factors

Assess your Symptoms

Heavy, Painful Legs? 2,3

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Legs that feel heavy, painful and swollen can be a result of a fluid retention in the legs due to the poor blood circulation. This increased fluid retention leads to the symptoms of Chronic Venous Insufficiency, which is a progressive disease can be worsen over time due to venous valves incompetence of the legs.

Healthy Veins 3

Vein valves are designed to allow blood to flow against gravity from the legs back to the heart.

Unhealthy Veins 3

When the values fail to close properly, gravity wins and the flow reverses. This is called venous reflux. Venous reflux is a progressive medical condition. If left untreated, it can worsen and cause more advanced symptoms of Chronic Venous Insufficiency.

Symptoms of Poor Blood Flow 1,2,3

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A range of signs and symptoms can point to poor blood flow in the legs. If you've been experiencing any of the following symptoms in your legs or ankles you should seek treatment as they can get worse over time.

feet of a heavy painful swollen leg

Heavy, Painful Legs or Edema

Tired Legs

Cramping or Leg pain

Spider Veins or Varicose Veins

Looks familiar?

If you regularly suffer from at least one of these symptoms, take our quick self-assessment quiz and use your result to help guide your next steps.

Start self-assessment

Treat Your Symptoms Early 1,2,4

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Heavy, painful legs and edema can be early signs of chronic venous insufficiency. Left untreated, these symptoms can increase in severity, leading to spider veins, varicose veins, and leg ulcers. The different stages of disease are described as grades C0-6 depending on the severity of the symptoms as shown here:

Stage 0

Heavy, Painful Legs

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Stage 0

Heavy, Painful Legs

No visible or palpable signs of venous disease, but symptoms include itching, pain, heaviness, leg-tiredness and muscle cramps

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Stage 1

Telangiectasiae /Reticular Veins

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Stage 1

Telangiectasiae /Reticular Veins

Ignoring initial symptoms can cause the condition to worsen, leading to broken blood vessels or “spider veins” and visible veins. They aren’t usually painful, but are an important indicator of leg vein problems. It’s important not to ignore this early sign as the condition can rapidly progress.

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varices visibles en la pierna

Stage 2

Varicose veins

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Stage 2

Varicose veins

Left untreated, stage 1 turns to stage 2 with the veins becoming unusually dilated, stretched out and sinuous. These obvious, bulging veins on the legs and ankles are a clear sign of chronic venous insufficiency.

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Stage 3

Edema

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Stage 3

Edema

Edema (swelling) may appear in stage 3 caused by increased pressure and leakage as a result of further deterioration of the venous walls and valves.

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Stage 4

Skin changes - Pigmentation and/or Eczema

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Stage 4

Skin changes - Pigmentation and/or Eczema

Continued poor circulation can lead to stage 4, characterised by darkening of the skin around your ankles (hyperpigmentation), redness, dryness, itchiness (venous eczema), hardening of soft tissues and the development of whitish patches.

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Stage 5

Healed venous ulcer

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Stage 5

Healed venous ulcer

Stage 5 is defined by the presence of open but healed areas of skin called ulcers. These can be painful and affect your quality of life, making it difficult to move around.

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Stage 6

Active venous ulcer

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Stage 6

Active venous ulcer

If you reach stage, you will have open wounds called ulcers on your legs. Internally at this stage there is more deterioration in circulation and increased leakage in the capillaries.

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If you are experiencing any of these signs and symptoms you should speak with your family doctor about the treatment options.

By recognizing the symptoms and take action, you can significantly reduce the possibility of disease progression and the impact on daily life.

RISK FACTORS YOU CAN CONTROL 3

Prolonged standing and sitting

Obesity

RISK FACTORS YOU CAN’T CONTROL 3

Age

Gender

Family history

Factors Affecting Blood Circulation

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There are several risk factors for Chronic Venous Insufficiency, although some of them are beyond your control, you can still rectify other risk factors. 1

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Women are tend to have more risk than men, and a family history, and aging can increase the chance of developing symptoms. 3

For lifestyle factors you can take steps to negate, such as being overweight and inactive, can also increase your risk of developing problems with your veins. Those who stand or sit as part of their occupations, such as nurses, teachers and those in the service industry, are particularly at risk. 3

Advice for Healthy Legs

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By incorporating simple habits into your daily routine and maintaining a healthy lifestyle, you can protect your legs from the discomfort caused by fluid retention and the damage this can cause to veins over time: 3,4

Stay active

Regular exercise helps improve circulation and tone the muscles in your legs.

Wear compression stockings

Compression stockings help to improve blood circulation in the legs.

Maintain a healthy weight

Keep a close eye on your weight as obesity can contribute to blocked or weakened valves in leg.

Avoid wearing high heels

Choose a medium heel over flat or high-heeled shoes to encourage more lower leg activity.

Wear loose clothing

Avoid tight clothing which can restrict blood flow in the legs and exacerbate the risk of chronic venous insufficiency.

Stay cool

Veins dilate in the heat which can cause blood to pool and contribute to your legs feeling heavy and tired.

Move regularly

Avoid sitting or standing for too long to prevent fluid retention in your legs.

Elevate your legs

Raise your legs and avoid crossing them to help blood flow towards the heart when relaxing.

In addition to lifestyle modifications, topical creams and gels can also be useful for symptom relief, and medical procedures can treat the advanced condition.

Safety Information:

Daflon 500mg Safety Information

COMPOSITION*: Micronized, purified flavonoid fraction 500 mg: 450 mg diosmin; 50 mg flavonoids expressed as hesperidin.

INDICATIONS*: Treatment of organic and idiopathic chronic venous insufficiency of the lower limbs with the following symptoms: heavy legs; pain; nocturnal cramps. Treatment of acute hemorrhoidal attacks.

DOSAGE AND ADMINISTRATION*: In venous disease: 2 tablets daily. In acute hemorrhoidal attacks: the dosage can be increased to up to 6 tablets daily.

CONTRAINDICATIONS*: Hypersensitivity to the active substance or to any of the excipients.

WARNINGS*: The administration of this product for the symptomatic treatment of acute hemorrhoids does not preclude treatment for other anal conditions. If symptoms do not subside promptly, a proctological examination should be performed and the treatment should be reviewed.

INTERACTION(S)*: None.

FERTILITY*. PREGNANCY/LACTATION*: Treatment should be avoided.

DRIVE & USE MACHINES*. UNDESIRABLE EFFECTS*: Common: diarrhoea, dyspepsia, nausea, vomiting. Rare: dizziness, headache, malaise, rash, pruritus, urticaria. Uncommon: colitis. Frequency not known abdominal pain, isolated face, lip, eyelid oedema. Exceptionally Quincke’s oedema.

OVERDOSE*. PROPERTIES*: Vascular protector and venotonic. Daflon 500 mg acts on the return vascular system: it reduces venous distensibility and venous stasis; in the microcirculation, it normalizes capillary permeability and reinforces capillary resistance.

PRESENTATION*: Pack of 30 film-coated tablets of Daflon 500 mg.

Servier Hong Kong Limited Room103, 31/F, Tower 5, The Gateway, 15 Canton Road, Harbour City, Tsim Sha Tsui, Kowloon, Hong Kong. www.servier.hk

*For complete information, please refer to the Summary of Product Characteristics.

Daflon 1000mg Safety Information

COMPOSITION*: Micronized, purified flavonoid fraction 1000 mg: 900 mg diosmin; 100 mg flavonoids expressed as hesperidine.

INDICATIONS*: Treatment of the symptoms of chronic venous disease of the lower limbs, either organic or functional: feeling of heavy legs, pain, night cramps. Treatment of acute hemorrhoidal episodes.

DOSAGE AND ADMINISTRATION*: In venous disease: 1000mg daily. In acute hemorrhoidal attacks: the dosage can be increased up to 3000mg daily.

CONTRAINDICATIONS*: Hypersensitivity to the active substance or to any of the excipients.

WARNINGS*: The administration of this product for the symptomatic treatment of acute hemorrhoids does not preclude treatment for other anal conditions. If symptoms do not subside promptly, a proctological examination should be performed and the treatment should be reviewed.

INTERACTION(S)*: None.

FERTILITY/PREGNANCY/LACTATION*: Treatment should be avoided.

DRIVE & USE MACHINES/UNDESIRABLE EFFECTS*: Common: diarrhoea, dyspepsia, nausea, vomiting. Rare: dizziness, headache, malaise, rash, pruritus, urticaria. Uncommon: colitis. Frequency not known abdominal pain, isolated face, lip, eyelid oedema. Exceptionally Quincke’s oedema.

OVERDOSE/PROPERTIES*: Vascular protector and venotonic. Daflon 500 mg acts on the return vascular system: it reduces venous distensibility and venous stasis; in the microcirculation, it normalizes capillary permeability and reinforces capillary resistance.

PRESENTATION*: Pack of 30 film-coated tablets of Daflon 500 mg.

Servier Hong Kong Limited Room 103, 31/F, The Gateway Tower 5, 15 Canton Road, Tsim Sha Tsui, Kowloon, Hong Kong www.servier.hk

*For complete information, please refer to the complete Summary of Product Characteristics for your country.

References:

  1. Nicolaides A, et al. Part I. Int Angiol. 2018;37(3):181-254.
  2. Bergan JJ et al. N Engl J Med. 2006;355:488-498​
  3. Vascular Disease Foundation. Available at: http://vasculardisease.org/flyers/chronic-venous-insufficiency-flyer.pdf (Accessed April 19, 2022).
  4. Nicolaides A, et al. International Angiology. 2020 Part II; DOI: 10.23736/S0392-9590.20.04388-6.

2024