Composition & Production

Composition of daflon 500mg

Daflon 500mg consists of a micronized purified flavonoid fraction of:

  • 90 % of diosmin,
  • 10 % of effective flavonoids, skilfully measured and obtained by hemisynthesis14.

Manufacturing process of Daflon 500mg

The manufacturing of Daflon 500mg begins with the harvest of small immature oranges in every corner of the world.

This natural compound is then transformed into a formula of flavonoids at the end of these 6 stages of manufacturing: 

Stage 1: the harvest of small immature oranges

Immature oranges are harvested in the orange groves of the Spanish, Moroccan and Chinese provinces, places benefiting from favorable weather conditions.

Indeed, every orange blossom gives birth to four or five oranges. A single orange develops and three or four others remain immature. These immature oranges will be harvested, dried during 15 days in the sun then crushed to extract a natural substance which will be used in the manufacturing of a drug called hesperidin.

Stage 2: birth of an active ingredient: the flavonoid fraction 

Once extracted, hesperidin is transformed by an industrial process into an active substance: the flavonoid fraction. This industrial process confers the flavonoid fraction a composition of: 90 % diosmin and 10 % flavonoids skilfully measured.

Stage 3: purification of the flavonoid fraction

The flavonoid fraction is then purified and dried to remove all the impurities. The objective of this stage is to obtain a flavonoid fraction of quality. 

Stage 4: micronization of the purified flavonoid fraction

The process of micronization thus consists of reducing the size of molecules and the micronized purified flavonoid fraction is then better absorbed by the body15

Stage 5: compression of the purified micronized flavonoid fraction

The purified micronized flavonoid fraction is then transformed into tablets of daflon 500mg thanks to the machine with compression.

Stage 6: box of daflon 500mg

Tablets are then put under blister packaging (blister of tablets) and incorporated into the Daflon 500mg box.

Daflon 500mg – Micronized purified flavonoid fraction (MPFF)

Daflon 500mg is a drug recommended in the treatment of the symptoms of the lower limbs (feeling of heaviness, pain, night cramps) and anal pain1,3.

Ask advice from your pharmacist. Read attentively the instructions before use. If the symptoms persist, consult your doctor.

References : 1- Nicolaides A et al. Int Angiol.2014 ;33(2):126-139. 3- Cospite M. Angiology.1994; 45(6-Part 2):566-573. 
Paysant J et al. Int Angiol 2008; 81-85. 15- Garner RC et al. J Pharm Sol;91:32-40.