Daflon. An effective oral treatment for reducing and relieving of anal pain and bleeding.

No. 1 Doctor recommended venoactive drug worldwide. 1

How does Daflon work?

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Daflon is a convenient oral venoactive treatment that gets to the root of anal pain and bleeding by working to treat the veins that become dilated and inflamed in the anal cushions which consist of vascular tissue. 2

Daflon can strengthen the overall tone of your veins, helping to improve blood flow and reducing venous congestion. It quickly relieves the signs and symptoms (e.g. anal bleeding, anal discomfort, pain, edema and anal discharge) in short term and reduces risk of relapse in long term. 2,3,4

Formulated for Fast Absorption and Relief

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Daflon is a clinically proven, effective and discrete oral treatment derived from natural ingredients and specially formulated for maximum absorption. 2,5

This improved absorption means Daflon can rapidly get to the root of the problem to conveniently and discretely reduce the duration, intensity and recurrence of signs and symptoms like anal pain and bleeding, for both fast-acting treatment of acute episodes, and ongoing maintenance for recurrence. 2,6

Rapid Relief and Long Term Improvement

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Daflon is clinically proven to quickly and effectively relieves anal pain and bleeding. Starting from 2 days, most people reported that their symptoms, anal bleeding, anal discomfort, pain and anal discharge had improved. In only 3 days, 80% reported that their bleeding had stopped. 2,4,6,7

Daflon can also be used for up to 2 months to treat chronic and recurring signs and symptom (e.g. anal pain and bleeding). With just 2 pills a day, 71% of users reported fewer instances of acute symptoms. 3

Rapid relief for Anal Pain, Bleeding and discharge

At 2 days

42% of patients experienced mild reduction of symptoms 7

At 3 days

80% of patients' bleeding stopped 6

At 7 days

94% of patients' bleeding stopped 6 84% of patients' pain stopped 7 81% of patients' discharge stopped 7

Ongoing treatment for Recurrent Anal Symptoms

At 2 months

31% Less severe symptoms 3

43% Shorter duration of symptoms 3

71% fewer recurences 3

Naturally sourced, scientifically prepared.

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The active ingredient in Daflon is a unique micronized purified flavonoid fraction (MPFF) containing 5 flavonoids, 90% micronized diosmin and 10% other active flavonoids (hesperidin, diosmetin, linarin and isorhoifolin). 4,9

Daflon's flavonoids are extracted from immature oranges that are rich in these naturally occurring plant chemicals. The compounds undergo a process of purification and refinement where the particles are made to collide with each other at high speeds (micronization), reducing them to tiny particles, less than 2 μm in size (micronized). These smaller particles are absorbed twice as easy by the body and a key ingredient of Daflon's success as a treatment for improving vein health and tone in Chronic Venous Insufficiency, anal tissues, and cushions. 4,5

Safety Information:

Daflon 500mg Safety Information

COMPOSITION*: Micronized, purified flavonoid fraction 500 mg: 450 mg diosmin; 50 mg flavonoids expressed as hesperidin.

INDICATIONS*: Treatment of organic and idiopathic chronic venous insufficiency of the lower limbs with the following symptoms: heavy legs; pain; nocturnal cramps. Treatment of acute hemorrhoidal attacks.

DOSAGE AND ADMINISTRATION*: In venous disease: 2 tablets daily. In acute hemorrhoidal attacks: the dosage can be increased to up to 6 tablets daily.

CONTRAINDICATIONS*: Hypersensitivity to the active substance or to any of the excipients.

WARNINGS*: The administration of this product for the symptomatic treatment of acute hemorrhoids does not preclude treatment for other anal conditions. If symptoms do not subside promptly, a proctological examination should be performed and the treatment should be reviewed.

INTERACTION(S)*: None.

FERTILITY*. PREGNANCY/LACTATION*: Treatment should be avoided.

DRIVE & USE MACHINES*. UNDESIRABLE EFFECTS*: Common: diarrhoea, dyspepsia, nausea, vomiting. Rare: dizziness, headache, malaise, rash, pruritus, urticaria. Uncommon: colitis. Frequency not known abdominal pain, isolated face, lip, eyelid oedema. Exceptionally Quincke’s oedema.

OVERDOSE*. PROPERTIES*: Vascular protector and venotonic. Daflon 500 mg acts on the return vascular system: it reduces venous distensibility and venous stasis; in the microcirculation, it normalizes capillary permeability and reinforces capillary resistance.

PRESENTATION*: Pack of 30 film-coated tablets of Daflon 500 mg.

Servier Hong Kong Limited Room 103, 31/F, The Gateway Tower 5, 15 Canton Road, Tsim Sha Tsui, Kowloon, Hong Kong www.servier.hk

*For complete information, please refer to the Summary of Product Characteristics.

Daflon 1000mg Safety Information

COMPOSITION*: Micronized, purified flavonoid fraction 1000 mg: 900 mg diosmin; 100 mg flavonoids expressed as hesperidine.

INDICATIONS*: Treatment of the symptoms of chronic venous disease of the lower limbs, either organic or functional: feeling of heavy legs, pain, night cramps. Treatment of acute hemorrhoidal episodes.

DOSAGE AND ADMINISTRATION*: In venous disease: 1000mg daily. In acute hemorrhoidal attacks: the dosage can be increased up to 3000mg daily.

CONTRAINDICATIONS*: Hypersensitivity to the active substance or to any of the excipients.

WARNINGS*: The administration of this product for the symptomatic treatment of acute hemorrhoids does not preclude treatment for other anal conditions. If symptoms do not subside promptly, a proctological examination should be performed and the treatment should be reviewed.

INTERACTION(S)*: None.

FERTILITY/PREGNANCY/LACTATION*: Treatment should be avoided.

DRIVE & USE MACHINES/UNDESIRABLE EFFECTS*: Common: diarrhoea, dyspepsia, nausea, vomiting. Rare: dizziness, headache, malaise, rash, pruritus, urticaria. Uncommon: colitis. Frequency not known abdominal pain, isolated face, lip, eyelid oedema. Exceptionally Quincke’s oedema.

OVERDOSE/PROPERTIES*: Vascular protector and venotonic. Daflon 500 mg acts on the return vascular system: it reduces venous distensibility and venous stasis; in the microcirculation, it normalizes capillary permeability and reinforces capillary resistance.

PRESENTATION*: Pack of 30 film-coated tablets of Daflon 500 mg.

Servier Hong Kong Limited Room103, 31/F, Tower 5, The Gateway, 15 Canton Road, Harbour City, Tsim Sha Tsui, Kowloon, Hong Kong. www.servier.hk

*For complete information, please refer to the complete Summary of Product Characteristics for your country.

References:

  1. IQVIA Daflon sales data MAT Q2 2021
  2. Shelygin Y, et al. Curr Med Res Opin. 2016;32(11):1821-1826. DOI: 10.1080/03007995.2016.1211520.
  3. Godeberge P. Phlebology. 1992;7 (suppl 2):61-63.
  4. Godeberge P., et al. J Comp Eff Res 2021;10(10):801-813.
  5. Garner RC, et al. J Pharm Sci. 2002;91(1):32-40.
  6. Misra MC, et al. Br J Surg. 2000;87(7):868-872.
  7. Cospite M. Angiology. 1994;45:566-573.
  8. Greenspon J. et al. Dis Colon Rectum. 2004. 47(9):1493-1498. DOI: 10.1007/s10350-004-0607-y.
  9. Daflon Summary of Product Characteristics

2024