Stop, Relieve and Prevent relapse with Daflon

Daflon is an effective oral treatment for the reduction and relief of anal pain. 1

Reason of Anal Pain?

Typically, anal swelling leads to anal discomfort and itchiness which you might feel a bulge in your bottom, experience anal pain, prolapse and inflammation, or bleeding when using the toilet. 2 Anal pain is an untold condition for a large part of the population and there are therapeutic solutions to relieve your concerns. 3

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It is not bothering you and affect your quality of life anymore.

Reason of Anal Pain?

What are the signs and symptoms?

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If you are experiencing this or any of the illustrated symptoms for the first time (or if your symptoms extend beyond a couple of days), you should consult a health care professional to rule out other conditions instead of self-treating right away. 6

Incomplete evacuation

Bleeding

Itchy bottom

Pain or discomfort

Looks familiar?

Daflon is a medicinal product that treats the underlying cause of anal pain for rapid relief and prevention of recurring symptoms. 1,4

Treat Your Symptoms Early

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Anorectal condition with symptomatic enlargement and distal displacement of the normal anal cushions is very common. They affect millions of people around the world, and represent a major medical and socioeconomic problem. 3

One of the most common manifestation is painless rectal bleeding associated with bowel movement, described by patients as blood drips into toilet bowl. 3

Grade 1

Bleeding​, Visible on proctoscopy, Protrude on straining​, No prolapse 3,5

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Grade 1

There may be bleeding, discomfort and itching, and protrusion on straining, but no evidence of prolapse. It is nonetheless essential that you treat from this first stage to avoid worsening symptoms.

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Grade 2

Bleeding​, Prolapse visible at anal margin during straining, Spontaneous return when straining ends 3,5

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Grade 2

Without treatment, your condition may worsen, leading to pain when using the toilet, bleeding and anal cushions that tend to prolapse when straining, but reduce when straining ceases.

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Grade 3

Bleeding​, Protrude on straining, Prolapse requiring manual reduction 3,5

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Grade 3

Bleeding is more frequent and your piles will prolapse on straining and need to be pushed back in. You can do this yourself. If there is a thrombosis (blood clot inside the vein) as well, the pain may be very strong.​

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Grade 4

Permanent and irreducible prolapse​, Bleeding​, Discharge 3,5

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Grade 4

Is the most serious stage. You will have permanent anal cushions that you can’t push back in yourself without pain in addition to previous signs and symptoms. Surgery in addition to venoactive treatments such as Daflon becomes essential.

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The main symptoms, including bleeding, pain, swelling and itching, that can occur at all grades. 2

RISK FACTORS YOU CAN CONTROL 5,6

Inactivity

Constipation / Diarrhea

Unfavorable diet e.g. inadequate dietary fiber, spicy diet, alcohol intake

Toilet habits e.g. prolong sitting on the toilet

RISK FACTORS YOU CAN’T CONTROL 5,6

Age

Pregnancy

What are the risk factors?

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Main risk factors include chronic constipation, obesity, increasing age or pregnancy. But there are many reasons you might find yourself looking for solutions to relieve your pain and bleeding, some of which you can take steps to change.

What should I do for relieving the symptoms and anal bleeding?

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Overall dietary and lifestyle modification can help prevent the excess pressure and damage to the anal cushions. Try incorporating some of the following advice into your daily routine to help protect against the occurrence of anal symptoms and their recurrence. 3,6

Eat high fibre foods

Try including more high fiber foods in your diet such as fruits, vegetables, brown rice, wholewheat pasta and wholemeal breads. These will keep your stools soft and avoid constipation (which can help to avoid hard stool on the anal mucosa which may cause damage to the anal cushions).

Exercise

Regular exercise will help relax muscles and increase blood flow for better healing.

Drink plenty of fluids

Drinking plenty of fluids (especially water) will help keep your stools soft and manageable.

Go when you need to

If you wait to pass a bowel movement, it can result in your stool becoming dry and harder to pass.

Try a fibre supplement

A fiber supplement can help ensure you are getting enough fiber in your diet if you struggle to get enough through foods.

Avoid sitting for too long

Sitting for too long, particularly on the toilet can increase the pressure on the veins around your anus making them more susceptible to prolapse.

Don’t strain

Straining on the toilet can put even more unwanted pressure on the blood vessels and aggravate an already sensitive area.

In addition to lifestyle modifications, there are a range of treatments available for easing relieving symptoms such as anal pain and bleeding, including oral flavonoids agents (Daflon) , gels, creams and suppositories.

Safety Information:

Daflon 500mg Safety Information

COMPOSITION*: Micronized, purified flavonoid fraction 500 mg: 450 mg diosmin; 50 mg flavonoids expressed as hesperidin.

INDICATIONS*: Treatment of organic and idiopathic chronic venous insufficiency of the lower limbs with the following symptoms: heavy legs; pain; nocturnal cramps. Treatment of acute hemorrhoidal attacks.

DOSAGE AND ADMINISTRATION*: In venous disease: 2 tablets daily. In acute hemorrhoidal attacks: the dosage can be increased to up to 6 tablets daily.

CONTRAINDICATIONS*: Hypersensitivity to the active substance or to any of the excipients.

WARNINGS*: The administration of this product for the symptomatic treatment of acute hemorrhoids does not preclude treatment for other anal conditions. If symptoms do not subside promptly, a proctological examination should be performed and the treatment should be reviewed.

INTERACTION(S)*: None.

FERTILITY*. PREGNANCY/LACTATION*: Treatment should be avoided.

DRIVE & USE MACHINES*. UNDESIRABLE EFFECTS*: Common: diarrhoea, dyspepsia, nausea, vomiting. Rare: dizziness, headache, malaise, rash, pruritus, urticaria. Uncommon: colitis. Frequency not known abdominal pain, isolated face, lip, eyelid oedema. Exceptionally Quincke’s oedema.

OVERDOSE*. PROPERTIES*: Vascular protector and venotonic. Daflon 500 mg acts on the return vascular system: it reduces venous distensibility and venous stasis; in the microcirculation, it normalizes capillary permeability and reinforces capillary resistance.

PRESENTATION*: Pack of 30 film-coated tablets of Daflon 500 mg.

Servier Hong Kong Limited Room 103, 31/F, The Gateway Tower 5, 15 Canton Road, Tsim Sha Tsui, Kowloon, Hong Kong www.servier.hk

*For complete information, please refer to the Summary of Product Characteristics.

Daflon 1000mg Safety Information

COMPOSITION*: Micronized, purified flavonoid fraction 1000 mg: 900 mg diosmin; 100 mg flavonoids expressed as hesperidine.

INDICATIONS*: Treatment of the symptoms of chronic venous disease of the lower limbs, either organic or functional: feeling of heavy legs, pain, night cramps. Treatment of acute hemorrhoidal episodes.

DOSAGE AND ADMINISTRATION*: In venous disease: 1000mg daily. In acute hemorrhoidal attacks: the dosage can be increased up to 3000mg daily.

CONTRAINDICATIONS*: Hypersensitivity to the active substance or to any of the excipients.

WARNINGS*: The administration of this product for the symptomatic treatment of acute hemorrhoids does not preclude treatment for other anal conditions. If symptoms do not subside promptly, a proctological examination should be performed and the treatment should be reviewed.

INTERACTION(S)*: None.

FERTILITY/PREGNANCY/LACTATION*: Treatment should be avoided.

DRIVE & USE MACHINES/UNDESIRABLE EFFECTS*: Common: diarrhoea, dyspepsia, nausea, vomiting. Rare: dizziness, headache, malaise, rash, pruritus, urticaria. Uncommon: colitis. Frequency not known abdominal pain, isolated face, lip, eyelid oedema. Exceptionally Quincke’s oedema.

OVERDOSE/PROPERTIES*: Vascular protector and venotonic. Daflon 500 mg acts on the return vascular system: it reduces venous distensibility and venous stasis; in the microcirculation, it normalizes capillary permeability and reinforces capillary resistance.

PRESENTATION*: Pack of 30 film-coated tablets of Daflon 500 mg.

Servier Hong Kong Limited Room 103, 31/F, The Gateway Tower 5, 15 Canton Road, Tsim Sha Tsui, Kowloon, Hong Kong www.servier.hk

*For complete information, please refer to the complete Summary of Product Characteristics for your country.

References:

  1. Shelygin Y, et al. Curr Med Res Opin. 2016;32(11):1821-1826. DOI: 10.1080/03007995.2016.1211520.
  2. Godeberge P, et al., J. Gastroenterol and Hepatol. 2020; 35:577-585. DOI:10.1111/jgh.14857. 
  3. Lohsiriwat V, et al. World J Gastroenterol 2012 May 7; 18(17): 2009-2017. DOI:10.3748/wjg.v18.i17.2009.
  4. Godeberge P. Phlebology. 1992;7 (suppl 2):61-63.
  5. Caren G, et al. N Engl J Med 2014;371:944-951. DOI: 10.1056/NEJMcp1204188.
  6. Godeberge P, et al. J Comp Eff Res 2021;10(10):801-813.

2024